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为肝细胞癌的协同光免疫疗法进行工程NIR响应的外体

Youbo Zhao^1,2, Yanan Li³, Zhiwei He^1,2

¹Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, Guiyang 550001, P. R. China.

|June 30, 2025

概括

工程外体可以远程重塑肝细胞癌.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

T细胞免疫疗法在癌症治疗方面表现有前途.
招募T细胞进入瘤微环境 (TME) 是一个临床挑战.
肝细胞癌 (HCC) TME通常具有免疫抑制作用.

研究的目的:

开发一种外体 (EXO) 免疫疗法来重塑免疫抑制性HCC TME.
为远程控制TME重塑和T细胞招募而设计外体.

主要方法:

工程外体 (cypate@EXO-CXCL9) 来自具有CXCL9和光热传感器的HCC细胞.
在HCC部位上对外体积累的同型向.
近红外光激活以诱导免疫细胞死亡并释放CXCL9.

主要成果:

工程外生体有效地准了HCC.
光热效应诱导了瘤细胞死亡和外体细胞破坏.
释放的CXCL9吸引了T细胞,激活了抗瘤免疫力.

结论:

这种基于外体的免疫疗法远程重塑了HCC微环境.
该策略增强了T细胞的招募和抗瘤免疫力.
为改善固体瘤免疫治疗提供了一种新的方法.

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