酸微粒对抗鼻腔和口腔细菌:合成,分析表征和生物相容性
Lorena Reyes-Carmona1, Margherita Izzi2, Rosaria Anna Picca2
1Laboratorio de Biointerfases, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Circuito exterior s/n, Ciudad Universitaria, CDMX 04510, México.
ACS omega
|June 30, 2025
概括
酸微粒对医院和口腔病原体具有强大的抗菌活性. 这些生物相容材料为医学和牙科开发新的抗菌生物材料提供了有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 纳米技术纳米技术
背景情况:
- 鼻腔感染和口腔病原体,如牙周炎,对健康构成重大挑战.
- 由于过度使用,抗生素耐药性正在增加,需要新的抗菌剂.
- 衍生化合物显示出作为生物材料的生物相容性和抗菌剂的前景.
研究的目的:
- 为了合成和表征酸微粒.
- 评估酸微粒对医院和口腔细菌的抗菌疗效.
- 评估酸微粒与人类纤维细胞和骨质细胞的生物相容性.
主要方法:
- 化学沉用于酸微粒合成.
- 使用FTIR,DLS,TEM,XRD和XPS进行表征.
- 对八种细菌的抗菌分析和对人类纤维细胞和骨质细胞的细胞毒性测试.
主要成果:
- 合成的酸微粒呈现出延长的形态和hopeite晶体结构.
- 颗粒体表现出高抗菌活性,对大多数测试的细菌实现了近100%的抑制.
- 在0.050.4毫克/毫升的度范围内,在人类纤维细胞和骨质细胞上观察到非细胞毒性作用.
结论:
- 酸微粒对关键病原体具有显著的抗菌特性.
- 合成的微粒与人类细胞具有生物相容性,这表明医疗应用的安全性.
- 这些发现凸显了酸微粒在牙科和医疗领域的抗菌生物材料中使用的潜力.
相关概念视频
Special Staining Techniques
1.7K
Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...
1.7K
Microbial Corrosion
93
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
93
Probiotics
296
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
296
The Oral Microbiota
90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
Microbiota of the Respiratory Tract
55
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
55
Microbiota of the Stomach and Small Intestine
77
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
77


