E-PASS评分系统的综合风险评分为新辅助疗法和治疗食道癌手术后患者的预后指标:一项多中心回顾性研究
Nanjing Li1, Yixin Liu2, Jianfeng Zhou2
1Division of Radiotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Frontiers in oncology
|June 30, 2025
概括
综合风险评分 (CRS) 有效地预测了接受新辅助化疗和手术的食道癌患者的结果. 高CRS表明并发症风险更大,存活率更低,有助于在手术前对患者进行评估.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 临床风险评估临床风险评估
背景情况:
- 局部晚期食道癌的标准治疗包括新辅助化学放射治疗 (nCRT) 和手术.
- 术后发病率和长期存活率仍然低于最佳水平,尽管目前的治疗方法.
- 术前风险评估对于识别高风险患者和预测不良结果至关重要.
研究的目的:
- 评估生理能力和手术压力估计 (E-PASS) 评分系统.
- 评估E-PASS对食道癌患者短期和长期结果的预测价值.
- 在这个患者群体中确定综合风险评分 (CRS) 的有用性.
主要方法:
- 追溯招募814名食道癌患者,接受治疗切除 (2010-2022年).
- 根据对整体生存率 (OS) 曲线应用的尤登指数,将队列划分为低和高的综合风险评分 (CRS) 组.
- 使用考克斯回归和卡普兰-梅尔分析评估的预测值.
主要成果:
- 在预测术后并发症方面,CRS表现出高的特异性和敏感性 (AUC=0.889发生,0.838严重程度).
- 多变量分析证实CRS是OS (HR: 1.48) 和无复发生存 (RFS) (HR: 1.44) 的独立预后因素.
- 高CRS组显示较差的长期OS和RFS结果,独立于瘤回归和阶段.
结论:
- 电子通行证评分系统是短期和长期结果的有价值的预测器.
- CRS有效地识别出患有并发症风险较高和生存率较差的患者.
- 这种评分系统可以帮助食道癌患者进行术前风险分层.
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