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Updated: Jun 27, 2026

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合成和生物评估基于西米卡巴的抗体-药物联合体

Nandan Sheernaly1, Irene Shajan2, Axel Steinbrueck1

  • 1Faculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr-University Bochum Universitaetsstrasse 150 44801 Bochum Germany nils.metzler-nolte@ruhr-uni-bochum.de.

RSC medicinal chemistry
|June 30, 2025
PubMed
概括

新的抗体-药物结合物 (ADC) 是通过将二-皮里迪尔-提奥西米卡巴 (DpT) 金属合剂与特拉斯图祖马布结合而形成的. 这种方法增强了癌细胞的向性和选择性,显示了改善癌症治疗的希望.

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Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...