使用GLP-1受体激动剂的2型糖尿病成年人的营养缺乏和肌肉损失:一项追溯观察性研究
W Scott Butsch1, Suela Sulo2, Andrew T Chang3
1Cleveland Clinic, Bariatric and Metabolic Institute, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Obesity pillars
|June 30, 2025
概括
类似葡萄糖-1受体激活剂 (GLP-1RAs) 可以导致营养缺乏症,超过20%的患者在一年内被诊断出这种疾病. 早期的饮食师参与可能会影响缺乏率,强调需要进行营养监测.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类似葡萄糖-1受体激动剂 (GLP-1RAs) 通过减少脂肪质量来促进减肥.
- 这种减肥可能伴随着意想不到的后果,包括营养缺乏和肌肉质量损失.
- 在使用GLP-1RAs的患者中量化这些营养风险对于患者的安全至关重要.
研究的目的:
- 量化接受GLP-1RAs治疗的成年人营养缺乏症的发生率.
- 评估早期咨询营养学家对营养缺乏发生的影响.
- 为了确定与GLP-1RA治疗相关的常见营养缺乏症.
主要方法:
- 来自461,382名成年GLP-1RA用户 (2017-2021) 的非识别索赔数据的回顾性分析.
- 包括患有或没有2型糖尿病,糖尿病前期或没有糖尿病诊断的患者.
- 与非GLP-1RA用户进行倾向匹配的比较,并分析饮食师访问对6个月和12个月缺陷率的影响.
主要成果:
- 在GLP-1RA启动后6个月内,12.7%的患者和12个月内22.4%的患者被诊断出营养缺陷.
- 维生素D缺乏是最常见的,在12个月后发生率为13.6%.
- 在6个月内访问饮食师的患者与没有饮食师的患者相比,缺乏诊断或并发症的发生率不同.
结论:
- 超过20%的开始GLP-1RA治疗的患者在一年内发展出营养缺乏症.
- 在这种患者群体中,维生素D缺乏是常见的担忧.
- 将营养专家,包括营养学家,纳入患者护理中,对于监测和管理缺陷至关重要.
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