COVID-19和复发性静脉血栓塞栓症 (CORE-VTE) 的研究结果
Jesalyn Clarkson1, Micheal Guirguis2, Xueyi Chen3
1, PharmD, is a Clinical Pharmacist with Alberta Health Services, Red Deer, Alberta.
The Canadian journal of hospital pharmacy
|June 30, 2025
概括
对于COVID-19相关的静脉血栓塞栓症 (VTE),3-6个月的抗凝剂治疗可能足够. 大多数患者被随访长期停药,静脉瘤复发和出血率较低.
科学领域:
- 医学研究 医学研究
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 与静脉血栓栓塞 (VTE) 的风险增加有关.
- 与COVID-19相关的VTE抗凝剂治疗的最佳持续时间仍然不确定.
- 这项研究调查了COVID-19后的VTE患者的治疗持续时间,复发和出血.
研究的目的:
- 为了确定COVID-19相关的VTE后填写的抗凝剂处方的持续时间.
- 评估患有静脉瘤复发的患者的比例.
- 评估该患者队列中出血事件的发生率.
主要方法:
- 加拿大阿尔伯塔省 (2020年2月 - 2022年6月) 的COVID-19相关VTE病例的回顾性队列研究.
- 使用国际疾病分类 (ICD-9/10) 代码识别的VTE和出血事件.
- 分析处方数据以确定抗凝药治疗的持续时间.
主要成果:
- 分析了822名患者;中位数随访时间为359天,其中大多数患者没有接受治疗.
- 平均抗凝药治疗持续时间为100天;43.8%的患者接受了0-3个月的治疗,28.5%的患者接受了4-6个月的治疗.
- 复发性VTE发生在6.0%的患者中,出血发生在8.8%的患者中.
结论:
- 在停止服用抗凝血药物后,很大一部分患者被长期跟踪.
- 考虑到复发和出血率较低,对于COVID-19相关的VTE,3-6个月的抗凝固药疗法似乎是合理的.
- 进一步的研究可能会根据个体风险因素来改进最佳治疗持续时间.
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