在COVID-19后的长期免疫变化以及BCG疫苗接种和潜在感染对疾病严重性的影响
Kamila Bendíčková1,2, Ioanna Papatheodorou1,2,3, Gabriela Blažková1
1International Clinical Research Center St. Anne's University Hospital Brno Czech Republic.
长期的COVID显著改变了免疫细胞,影响了髓状和淋巴状功能. 细菌卡尔梅特-盖林 (BCG) 疫苗可能会对严重的COVID-19和败血症提供一些保护,尽管需要进一步的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 研究SARS-CoV-2感染对免疫系统的长期影响至关重要.
- 细菌卡尔梅特-盖林 (BCG) 疫苗在调节对COVID-19和败血症免疫力的作用正在探索中.
- 了解BCG诱导的训练免疫力可能会揭示抗病毒感染及其并发症的保护机制.
研究的目的:
- 评估COVID-19严重程度对免疫细胞概况的长期影响.
- 为了确定BCG疫苗接种,潜伏感染和COVID-19/败血症结果之间的关联.
- 检查之前的COVID-19和BCG状态对单细胞对二次挑战的反应的影响.
主要方法:
- 对97名COVID-19康复患者 (感染后3至17个月) 和64名败血症患者的前性分析.
- 评估免疫细胞频率和功能标记物表达 (骨髓和淋巴细胞).
- 用SARS-CoV-2和LPS进行抗体标位和体外单细胞刺激试验的分析.
主要成果:
- 在COVID-19后的患者中观察到免疫调节失调,骨髓状和淋巴状细胞标记物发生变化.
- 在危急COVID-19幸存者的CD8+T细胞上增加CD57表达.
- 在BCG血清阳性COVID-19/败血症患者中,改善结果的趋势,可能因年龄而混.
结论:
- COVID-19导致免疫细胞功能发生显著和持久的改变.
- 接种BCG疫苗可能有助于减轻COVID-19的严重程度和败血症的进展.
- 需要进一步的研究来证实BCG诱导的训练免疫的保护作用.
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