具有主观认知衰退的女性的功能连接性改变
Ashleigh F Parker1,2, Cassandra Szoeke3, Heather Kwan1,2
1Department of Psychology, University of Victoria, Victoria, BC, Canada.
Journal of Alzheimer's disease reports
|June 30, 2025
概括
与健康对照人群相比,主观认知衰退 (SCD) 的老年女性在关键网络中显示出大脑连接性增加. 这一发现表明女性阿尔茨海默病 (AD) 风险的潜在早期标志物.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 不成比例地影响女性,目前是无法治愈的.
- 主观认知衰退 (SCD) 代表了AD发展的早期风险阶段.
- 了解女性早期的AD标志物对于及时干预至关重要.
研究的目的:
- 调查健康的老年妇女和患有SCD的老年妇女之间的休息状态网络中的功能连接差异.
- 探索两个群体之间的人口,生活方式和并发症变化.
- 确定女性早期阿兹海默症风险的潜在神经影像生物标志物.
主要方法:
- 利用来自妇女健康老龄化计划 (WHAP) 的3T高分辨率静止状态fMRI扫描.
- 在FSL中采用基于种子的方法来分析默认模式网络 (DMN),前端对联网络 (FPN) 和突出网络 (SN) 中的功能连接.
- 对人口统计,生活方式和医疗并发症数据进行了群体比较.
主要成果:
- 与健康对照人群相比,患有SCD的老年女性在DMN和FPN内表现出显著增加的功能连接.
- 在人口统计学变量,生活方式因素或医疗并发症方面,两组之间没有发现显著差异.
结论:
- 女性自我报告的SCD与特定大脑网络的功能连接性增加有关.
- 这些连接变化可能是AD风险的早期指标.
- 需要进行进一步的研究,以探索这些发现对妇女的阿尔茨海默病预测和预防的影响.
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