均等性改变了与妊娠时间和出生体重相关的遗传变异的影响
Karin Ytterberg1, Hedvig Sundelin1, Julius Juodakis1
1Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
medRxiv : the preprint server for health sciences
|June 30, 2025
概括
平等性,即先前怀孕的数量,影响了对妊娠时间的遗传影响. 这项研究发现,对怀孕时间的遗传影响在母亲的第一次怀孕和随后的怀孕之间有所不同.
科学领域:
- 遗传学 是一个遗传学.
- 生殖生物学 生殖生物学
- 围产期健康 围产期健康
背景情况:
- 怀孕时间和出生体重影响母亲和后代的健康.
- 之前关于怀孕结果的遗传研究忽视了平等的作用.
- 同等性,定义为以前出生的人数,可能会改变遗传影响.
研究的目的:
- 调查平价是否会改变母亲或胎儿对妊娠时间和出生体重的遗传影响.
- 探索孕期结果中的基因×平价相互作用.
主要方法:
- 进行了对等分层的全基因组关联研究 (GWAS).
- 测试了单核酸多态 (SNP) ×平价相互作用.
- 评估了特征的多基因预测和平价相互作用.
- 通过使用挪威母亲,父亲和儿童队列研究 (多达58,528对母子) 的数据,评估了跨平价的遗传相关性.
主要成果:
- 分享和独特的遗传位置被确定为妊娠时间和出生体重在不同的平价.
- 这些结果的遗传相关性因平价而异.
- 最强有力的证据表明,对等性修饰遗传效应在母亲基因组中观察到妊娠时间,在第一次怀孕中效应更强烈.
- 发现孕期持续时间和平价性之间的母体多基因预测之间存在显著的相互作用 (p=5×10−5).
结论:
- 均等性显著改变了对妊娠时间的遗传影响.
- 基因与平价相互作用似乎主要局限于妊娠时间,对于出生体重的确定性较低.
- 考虑到对等性对于未来对妊娠结果的遗传研究至关重要.
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