在人类中使用SNSPD和高密度SPAD摄像头进行光学血流监测
medRxiv : the preprint server for health sciences
|June 30, 2025
概括
新的探测器增强了时间域扩散相关谱学 (TD-DCS) 以进行非侵入性脑血流监测. 这项技术为急性脑损伤管理提供了更好的深度灵敏度和信号质量.
科学领域:
- 生物医学光学 生物医学光学
- 医疗器械 医疗器械 医疗器械
- 神经科学是一个神经科学.
背景情况:
- 持续,非侵入性监测大脑血流 (CBF) 对于管理急性脑损伤至关重要.
- 时间域扩散相关谱 (TD-DCS) 提供深度敏感的微血管血流评估.
- 光子检测技术的进步是提高TD-DCS性能的关键.
研究的目的:
- 介绍TD-DCS使用超导纳米线单光子探测器 (SNSPD) 和高密度单光子雪崩二极管 (SPAD) 阵列的最新发展.
- 通过光子时隔和优化仪器响应功能来证明增强的信号噪声比 (SNR) 和深度灵敏度.
- 评估基于SPAD的TD-DCS系统的临床适用性.
主要方法:
- 在1064 nm运行的SNSPD和高密度SPAD阵列中实施TD-DCS.
- 应用光子时隔技术来改善信号的区分.
- 使用床头 (HOB) 和压力调制协议的系统验证,以及手握测试.
主要成果:
- 在1064 nm.表现出更好的SNR和深度灵敏度.
- 验证了系统使用HOB和压力调制来隔离更深层的大脑信号的能力.
- 基于SPAD的探测器显示了对CW-DCS的补充结果,在SNR和可扩展性方面提供了优势.
结论:
- 在临床 TD-DCS 实施中,SPAD 阵列是一个有希望的,可扩展的,具有成本效益的解决方案.
- SNSPD阵列为TD-DCS提供了可行的替代方案或补充,特别是在1064 nm的深层组织成像中.
- 这些进展为在临床环境中改善大脑血流的非侵入性监测铺平了道路.
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