在整个童年时期早产,社会经济地位和白质发育
Katie Mckinnon1, Manuel Blesa Cábez1,2, Melissa Thye2
1Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, UK.
medRxiv : the preprint server for health sciences
|June 30, 2025
概括
早产和社会经济地位 (SES) 影响大脑发育. 在5岁时,SES对白质微观结构的影响从基于家庭的措施转向基于社区的措施.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 过早出生和社会经济地位 (SES) 是影响早期大脑发育的已知因素.
- 妊娠年龄 (GA) 和SES对白质微观结构的长期综合影响仍然不清楚.
研究的目的:
- 研究妊娠年龄 (GA) 和社会经济地位 (SES) 对白质微观结构的影响.
- 在新生儿时期和5岁时检查这些影响.
主要方法:
- 扩散核磁共振被用来评估白质的微观结构 (分数异构性 - FA).
- 参与者包括早产和满期婴儿,五年后进行随访成像.
- 分析了GA,SES (母亲教育,苏格兰多重贫困指数 - SIMD) 和FA之间的关联,包括GA×SES相互作用.
主要成果:
- 在早产新生儿中,更高的GA和母亲的教育与更高的FA相关.
- GA-SES相互作用表明,GA-FA关联受到母亲教育和SIMD的影响.
- 在5岁时,GA和FA之间的关联主要取决于SIMD,而不是母亲的教育.
- 孕期婴儿仅在新生儿期显示较低的SES和较高的FA之间存在关联.
结论:
- 早产和SES都对从出生到5岁的大脑发育起了重大影响.
- 在早产婴儿中,SES影响白质微观结构的主要衡量标准是从家庭层面 (母亲教育) 过渡到5岁时的社区层面 (SIMD).
- 解决社会不平等对发展的影响的干预措施可能需要随着儿童的年龄增长而适应.
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