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循环肠道微生物代谢物和冠心病风险:一个前性的多阶段研究
medRxiv : the preprint server for health sciences
|June 30, 2025
概括
循环的肠道微生物代谢物与冠心病 (CHD) 风险有关. 确定并验证了五种关键代谢物,为新的生物标志物和疗法提供了潜力.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 心血管流行病学心血管流行病学
背景情况:
- 越来越多的证据将肠道微生物群与心脏代谢健康联系起来.
- 很少有研究系统地检查了循环中的微生物代谢物与发生的冠心病 (CHD) 相关的情况.
研究的目的:
- 系统地识别和验证与发生性心脏病相关的循环肠道微生物代谢物.
- 探索潜在的生物标志物和治疗点,以预防心脏病.
主要方法:
- 跨越五个潜在队伍的多阶段代谢学研究.
- 非向的血代谢物分析,用于发现,in-silico验证和有针对性的定量测定.
- 后勤和考克斯回归分析调整了社会人口统计学和生活方式因素.
主要成果:
- 确定了73种与微生物群相关的代谢物,与发现阶段的发生性心脏病相关.
- 验证了5种代谢物 (伊米达 propionate,3-hydroxy-2-ethylpropionate,4-hydroxyphenylacetate,trans-4-hydroxyproline,3-hydroxybutyrate) 与CHD有显著的关联.
- 发现的关联因种族,年龄,肥胖和高血压史而异.
结论:
- 识别和验证的循环肠道微生物代谢物与多种人群中发生性心脏病相关.
- 这些发现强调了肠道微生物代谢在心血管疾病发展中的重要性.
- 确定了用于进一步机械研究和治疗开发的特定代谢物.
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