量化早期生长逆境对后期健康的影响
Raphael Goldman-Pham1, Matthew P Alter1, Rebecca Bao1
1Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec Canada.
medRxiv : the preprint server for health sciences
|June 30, 2025
概括
成年人的新型身高差距指数反映了生命早期的成长逆境. 这种不利因素与所有原因和心血管死亡率的风险增加有关,突出显示了它对长期健康结果的影响.
科学领域:
- 人类发展 人类发展
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 早期生长逆境显著影响成年人的健康.
- 在成年期精确评估早期生长逆境是具有挑战性的.
- 这项研究探讨了高度差距作为新型指标的实用性.
研究的目的:
- 评估身高差距,即成年人达到的身高与基因型预测的身高之间的差异,是否与生命早期的生长逆境有关.
- 为了确定身高差距是否与晚年所有原因和心血管死亡率有关.
- 引入高度差距作为评估健康和健康平等发展起源的工具.
主要方法:
- 基因型预测的身高是使用多祖先多基因身高得分计算的.
- 高度差被计算为成年人测量和基因型预测的身高之间的差异.
- 使用回归模型分析了相关性,并在多个大型队列中复制 (ALSPAC,UKBiobank,DMHDS,MESA).
主要成果:
- 较低的妊娠年龄,更大的剥夺,烟雾暴露和更少的母乳养与ALSPAC中更大的身高差距缺陷有关.
- 在UKBiobank中,身高差距赤字与所有原因死亡率 (aHR: 1.25) 和心血管疾病死亡率 (aHR: 1.33) 的增加显著相关.
- 这些关联在DMHDS和MESA研究中得到了一致的复制.
结论:
- 高度差距作为一个有价值的指标,在成年后的早期生长逆境.
- 该指数可用于调查长寿和健康差异的发育起源.
- 这些发现支持使用身高差距来改善整个生命周期的健康平等.
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