内分泌干扰剂与神经退行性疾病之间的关系:系统性审查和元分析
Chengxing Wang1, Jie Xu1, Kai Pan1
1School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
iScience
|June 30, 2025
概括
暴露于内分泌干扰化学物质 (EDCs) 与神经退行性疾病 (NDs) 的风险增加有关. 这一元分析证实EDCs对神经健康的不良影响.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 内分泌干扰化学物质 (EDC) 是干扰激素系统的外源物质.
- 神经退行性疾病 (NDs) 构成了全球严重的健康负担.
- 关于EDC和ND之间的联系的现有证据需要更新的流行病学综合.
研究的目的:
- 进行一项元分析,评估关于EDC暴露和NDs之间的关联的流行病学证据.
- 综合从2003年1月至2023年12月出版的文献中的发现.
- 提供关于EDCs对神经健康构成的风险的最新见解.
主要方法:
- 在PubMed,Web of Science和Embase数据库中进行系统的文献搜索.
- 包括21项研究,包括286,610名受试者进行元分析.
- 使用几率比率 (OR) 和95%置信区间 (CI) 来评估风险和相关性的统计分析.
主要成果:
- 暴露于多双与NDs的风险增加有关 (OR=1.08,95% CI:1.03-1.14).
- 对有机化农药的暴露与ND风险呈正相关性 (OR = 1.11,95% CI: 1.05-1.17).
- 亚组分析表明EDC暴露与阿尔茨海默病 (OR = 1.03,95% CI: 1.00-1.07) 和肌缩侧面硬化症 (OR = 1.02,95% CI: 1.01-1.03) 之间的积极关联.
结论:
- 人类接触内分泌干扰化学物质对神经退行性疾病风险产生不利影响.
- 这些发现强调了监测和减轻EDC暴露的重要性,以保护神经健康.
- 这一元分析提供了强有力的流行病学证据,支持EDC和ND之间的联系.
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