与活跃肺结核相比,亚临床肺结核的特征:一个回顾性队列研究
Aiping Zhang1, Wenjie Wang1, Zijian Wang1
1Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu 241001 Anhui, PR China.
概括
亚临床肺结核 (SPTB) 影响年轻男性,与活性肺结核 (APTB) 相比,它显示出不同的实验室标记. 监测这些标志物有助于早期诊断和治疗SPTB.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 亚临床肺结核 (SPTB) 的诊断是具有挑战性的.
- 对SPTB的临床和实验室特征的了解有限.
研究的目的:
- 分析SPTB患者的实验室结果.
- 提高对SPTB的临床理解.
- 促进SPTB的早期诊断.
主要方法:
- 在中国进行的回顾性队列研究.
- 将138例SPTB病例与140例活跃肺结核病例 (APTB) 和136例健康对照 (HC) 进行了比较.
主要成果:
- SPTB患者的年龄较小 (40.43 ± 19.85岁),而不是APTB患者 (50.01 ± 21.49岁).
- 与HC相比,TB的两组白细胞 (WBC) 数量增加.
- 在APTB组中,C-反应蛋白 (CRP) 和CA-125的含量高于SPTB和HC组.
- 在SPTB组的CD4+T细胞数量低于HC组.
- 与HC相比,CD8+ T细胞计数在两组结核病中都较低.
- 在SPTB组中,T-SPOT.TB值低于APTB组.
结论:
- SPTB患者往往是年轻的,主要是男性.
- 监测白细胞计数,CA-125,CRP,T淋巴细胞计数和T-SPOT.TB值可以帮助预测SPTB向APTB的进展.
- 这些标志物支持SPTB的早期诊断和治疗.
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