与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 患者的胆结石预测因素
Uzma Soomro1, Ghulam Abbas2, Muhammad Aslam3
1General Surgery, Sindh Institute of Medical Sciences, Karachi, PAK.
在巴基斯坦,近30%的代谢功能障碍相关脂肪肝病 (MAFLD) 患者也患有胆结石病 (GSD). 在MAFLD患者中,胆结石的独立预测因素包括年龄较大,女性性别,糖尿病,性酸酶升高,低HDL和高空腹血糖.
科学领域:
- 肝病学和胃肠道学
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题,特别普遍存在于南亚.
- 胆结石病 (GSD) 与MAFLD共享代谢风险因素,包括肥胖,糖尿病和脂质失调症.
- 关于巴基斯坦MAFLD和GSD之间的关联,当地数据有限.
研究的目的:
- 在被诊断患有代谢功能障碍相关的脂肪肝病 (MAFLD) 的患者中调查胆结石病 (GSD) 的独立预测因素.
- 为了解决有关巴基斯坦人口中MAFLD和GSD共患病率的当地数据的稀缺性.
主要方法:
- 一项涉及350名成年MAFLD患者的横截面研究,这些患者在辛德省泌尿器科和移植研究所 (SIUT) 通过超声波诊断.
- 排除标准包括显著的酒精摄入量,先前存在的肝病,先前的胆囊切除术,怀孕和改变脂质的药物使用.
- 收集了人口统计,临床因素和实验室参数的数据,通过腹部超声波确定了GSD. 统计分析涉及单变量和多变量逻辑回归.
主要成果:
- 在350名MAFLD患者中,102名 (29.1%) 患有胆结石.
- 胆结石患者年龄大得多,女性更常见,糖尿病发病率更高.
- 在胆结石组中观察到性酸酶 (ALP),-胺转移酶 (GGT),总胆固醇,甘油三和禁食血糖 (FBS) 的升高,以及较低的高密度脂蛋白 (HDL) 水平.
结论:
- 老年,女性性别,糖尿病,高ALP,低HDL和高FBS被确定为MAFLD患者中GSD的独立预测因素.
- 该研究强调了特定的代谢和人口因素与MAFLD患者胆结石的存在之间的显著关联.
- 建议进一步进行多中心的前性研究,以验证这些发现,并探索更多的促成因素,如饮食,荷尔蒙和遗传学.
更多相关视频
07:12Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
Published on: June 2, 2023
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
相关概念视频
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
Chronic Pancreatitis II: Collaborative Care
Assessment:
