相关实验视频

Updated: Sep 17, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

现型属性和生存率在不匹配修复缺陷/微卫星不稳定性高的结直肠癌中

Anurag Mehta¹, Divya Bansal², Rupal Tripathi³

¹Department of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, Delhi, India.

World journal of clinical oncology

|June 30, 2025

概括

不匹配修复缺陷/微卫星不稳定性高 (MMR-D/MSI-H) 的结直肠癌表现出明显的特征和更好的生存率. MMR-D/MSI-H状态是结肠直肠癌 (CRC) 的一个有价值的预后因素.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
癌症研究癌症研究

背景情况:

不匹配修复缺陷/微卫星不稳定性高 (MMR-D/MSI-H) 的结直肠癌 (CRC) 与不匹配修复熟练/微卫星稳定 (MMR-P/MSS) 的CRC相比具有独特的基因组和表型特征.
传统的CRC预后因素包括阶段,瘤分化,位置,入侵,芽,瘤透淋巴细胞,淋巴结产量 (LNY) 和淋巴结比率 (LNR).

研究的目的:

为了确定MMR-D/MSI-HCRC的独特表型特征.
将LNY和LNR的预后意义与MMR-D/MSI-HCRC的独特特征相结合.

主要方法:

对223名在没有新辅助治疗的情况下进行手术切除的I-III期CRC患者的回顾性分析.
从患者记录和H&E染色幻灯片中评估临床和组织学特征.
使用免疫组织化学或MSI测试来确定MMR/MSI状态.

主要成果:

与MMR-D/MSI-HCRCs (39.01%) 相比,MMR-P/MSSCRCs (60.99%) 的位置,阶段,瘤芽,入侵,淋巴细胞反应,LNY,LNR和未参与的淋巴结大小存在显著差异.
在MMR-D/MSI-H组中,LNY和LNR显著更高 (分别P=0.003和P<0.001).
五年整体生存率为MMR-D/MSI-HCRCs的92%相对于MMR-P/MSSCRCs的71% (P<0.001).

结论:

MMR-D/MSI-H CRCs表现出明显的表型特征,包括一个增强的免疫反应,源于它们独特的基因组特征.
MMR-D/MSI-H状态在结直肠癌管理中具有显著的预后和预测价值.

关键词:

结肠直肠癌是什么意思淋巴结比率是淋巴结的比率.淋巴结产出了淋巴结的产量微卫星的不稳定性是微观的纠正不匹配的修复方法

更多相关视频

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

相关概念视频

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...