在缺血性心脏病中的光学治疗:从分子洞察到临床翻译
Yangjie Xiao1, Jing Zhang1, Lu Sun1
1Department of Ultrasound, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004 Liaoning, China.
Theranostics
|June 30, 2025
概括
光学治疗术为缺血性心脏病 (IHD) 提供先进的成像和治疗. 这种基于光的方法整合了诊断和治疗,尽管存在翻译方面的挑战,但它显示出改善心血管保健的前景.
科学领域:
- 生物医学工程 生物医学工程
- 心血管医学 心血管医学
- 光学成像和治疗疗法
背景情况:
- 准确的风险分层对于管理缺血性心脏病 (IHD) 至关重要,这是一个重大的全球健康问题.
- 光学治疗术,通过光线融合成像和治疗,为IHD管理提供了一种新的策略.
- 目前的心血管成像缺乏先进光学方法提供的实时功能和分子数据.
研究的目的:
- 审查目前用于缺血性心脏病 (IHD) 的光学治疗术的进展情况.
- 分析在IHD中光学治疗术的技术原则,临床前和临床应用以及转化障碍.
- 探索基于光的技术如何优化心血管保健IHD.
主要方法:
- 复习先进的光学成像模式:光学相干断层扫描,近红外光成像和光声学成像.
- 光疗策略的分析:图像引导的光动力学和光热疗法.
- 检查能够实现闭环诊断-治疗工作流程的综合疗法平台.
主要成果:
- 光学模式提供冠状动脉解剖学,心肌 perfusion 和分子生物标志物的高分辨率可视化.
- 光疗在临床前IHD模型中显示出治疗潜力.
- 集成平台允许成像指导治疗和监测治疗反应.
结论:
- 光学治疗术通过将精确的成像与向治疗相结合,为IHD管理提供了一种变革性的方法.
- 临床转化中的挑战,如有限的组织透和安全性,正在通过持续的发展得到解决.
- 对比剂的持续进步,设备的小型化和多式联络的整合是实现心血管护理光学疗程全能的关键.
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