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Updated: Apr 30, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

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可定制的双金属纳米酶通过抑制氧化应激和发炎来缓解椎间盘变性

Anran Zhang1, Haiyang Gao1, Xianglong Chen1

  • 1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Theranostics
|June 30, 2025
PubMed
概括

这项研究引入了一种新的双金属纳米酶,MPB-Mn3-CB,用于治疗椎间盘退化 (IDD). 它有效地清除活性氧物种 (ROS),增强细胞外基质 (ECM) 合成,并防止细胞核脉细胞 (NPC) 衰老.

关键词:
细胞衰老 细胞衰老细胞外矩阵是细胞外矩阵.椎间盘退化 椎间盘退化纳米酶纳米酶是一种纳米酶.氧化损伤是因为氧化损伤.

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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
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