硫酸与芬太尼作为用于下肢整形手术的外周麻醉的辅助剂:一项比较研究
Oluwole Fiwawola Olatunji1, Tinuola A Adigun2,3, Olayinka R Eyelade2,3
1Department of Anaesthesia and Critical Care, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, Nigeria.
Journal of the West African College of Surgeons
|June 30, 2025
概括
与芬太尼相比,硫酸作为外围注射辅助剂在下肢骨科手术中提供了优越的疼痛缓解. 这项研究发现,它显著改善了镇痛效果,并延长了疼痛管理的持续时间.
科学领域:
- 麻醉学 麻醉学
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 外周麻醉是下肢骨科手术期间管理疼痛的关键方法.
- 像硫酸和芬太尼这样的辅助剂用于增强外周麻醉的止痛特性.
研究的目的:
- 为了比较硫酸与芬太尼在选择性下肢骨科手术中作为外腔助剂缓解疼痛的疗效.
主要方法:
- 一项双盲随机研究,涉及96名接受下肢骨科手术的患者.
- 患者接受了腰部外周麻醉,用布皮瓦卡因与硫酸 (M组),芬太尼 (F组) 或普通盐水 (C组) 相结合.
- 关键的结果措施包括感觉和运动阻塞的开始和持续时间,以及达到数值评分表 (NRS) 疼痛分数为3的时间.
主要成果:
- 与芬太尼 (F) (20.5分, 26.6分) 和对照 (C) (23.7分, 29.8分) 组相比,硫酸 (M) 组显示感觉 (17.9分) 和运动 (24.5分) 阻塞的开始显著更快 (P=0.001).
- 外周麻醉的持续时间在硫酸组 (167.0分钟) 与芬太尼 (145.9分钟) 和对照组 (121.6分钟) 相比,在硫酸组 (167.0分钟) 显着更长 (P=0.001).
- 达到3的NRS疼痛评分的时间也与硫酸 (172.0分钟) 与芬太尼 (151.8分钟) 和对照 (133.2分钟) 相比显著延长 (P=0.001).
结论:
- 硫酸是一种比芬太尼在下肢骨科手术中的疼痛管理中更有效的外周助剂.
- 这些发现表明,硫酸可以增强外周麻醉所提供的止痛的开始和持续时间.
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