压力诱导的发育可塑性和自发的早产:以正义为导向的生态-evo-devo审查
Gabriella Mayne1, Luwam Ghidei2, Ayisha Buckley3
1Department of Health & Behavioral Sciences, University of Colorado, Denver, CO, USA.
概括
减少母亲的压力可以防止自发的早产,这是婴儿死亡的主要原因. 这种方法对于改善出生平等至关重要,特别是在边缘化社区.
科学领域:
- 综合生物学和社会科学,专注于生殖健康.
背景情况:
- 自发早产 (<37周孕期) 是新生儿发病率和死亡率的主要驱动因素.
- 边缘化社区因社会经济因素和种族主义而面临不成比例的高自发早产率.
- 孕产妇的压力是早产的重要风险因素,但在临床环境中没有充分解决.
研究的目的:
- 将减轻母亲的压力作为自发早产预防的关键策略.
- 整合来自生态-evo-devo生物学,黑人女权主义理论和生殖正义的见解.
- 突出解决母亲压力的潜力,以改善出生平等.
主要方法:
- 对文献的审查,将生态,进化和发育生物学与社会理论相结合.
- 通过保存的信号通路,分析母亲的压力作为影响妊娠的因素.
- 检查压力诱导的发育可塑性及其对妊娠时间的影响.
主要成果:
- 孕产妇的压力可以通过进化保存的孕产妇-胎儿-胎盘信号通路缩短妊娠期.
- 压力对孕期长度的影响似乎取决于剂量.
- 压力对妊娠的影响可能是可逆的,这表明可能需要干预.
结论:
- 减少孕产妇的压力是一个可行的临床策略,可以降低自发早产率.
- 针对母亲的压力可以有助于实现更大的出生平等.
- 跨学科的方法对于理解和解决复杂的生殖健康差异至关重要.
相关概念视频
Nature and Nurture
20.8K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.8K
Gene-Environment Interactions
576
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
576
Plasticity
2.5K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
2.5K
The Nativist Approach
145
The nativist approach to infant cognitive development proposes that infants are born with inherent knowledge structures that allow them to interpret the world almost immediately. This perspective contrasts with earlier developmental theories, such as those proposed by Jean Piaget, which emphasized a more gradual acquisition of cognitive abilities through interaction with the environment. One key concept in this approach is object permanence — the understanding that objects continue to...
145
Environmental Influences on Intelligence
432
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
432
Teratogenicity
2.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K


