抗胆固醇性认知负担的变化和一次性和反复性跌倒的风险:基于人口的队列研究
Xiang Jiang Xu1, Phyo Kyaw Myint2, Man Chun Wong2
1Department of Medicine, University of Malaya, Kuala Lumpur, 50603 Kuala Lumpur, Malaysia.
Age and ageing
|June 30, 2025
概括
抗胆固醇认知负担 (ACB) 药物使用增加了40岁以上的成年人反复跌倒的风险,无论随着时间的推移暴露的变化. 步行速度是增加跌倒风险的一个关键因素.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 高抗胆性认知负担 (ACB) 药物与老年人中跌倒风险增加有关.
- 随着时间的推移,ACB暴露的变化对跌倒风险的影响仍然不清楚.
研究的目的:
- 调查ACB暴露的变化与单次和反复跌倒的风险之间的关联.
主要方法:
- 利用了来自欧洲癌症调查-诺福克 (EPIC-Norfolk) 研究的数据 (n=10,717,年龄≥40).
- 将参与者分为四个ACB暴露组:没有,晚期,短暂和持续.
- 在第三次健康检查 (2004 - 11) 之前的12个月内评估一次性或反复性跌倒 (≥2).
主要成果:
- 与没有暴露相比,连续,晚期和短暂的ACB暴露与反复跌倒的增加显著相关.
- 调解分析表明步行速度 (GS) 占与ACB相关的反复跌倒风险增加的16.9%.
- 在14年的时间里,抗胆固醇药物的使用与反复跌倒有关,无论暴露是否开始或停止.
结论:
- 抗胆固醇药物的使用与40岁以上的成年人中经常性跌倒有关,即使暴露率波动.
- 步行速度可以作为一个有价值的工具,用于风险检测和监测,在开始服用抗胆固醇药物的个人.
- 需要进一步的研究来制定策略,以尽量减少与抗胆固醇药物使用相关的长期跌倒风险.
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