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在临床制造过程中评估基于微流体芯片的细胞分类器,以耗尽或分离CD4调节性T细胞

Ruud Hulspas1,2, M Felicia Ciuculescu1, Carolina Sasso1

  • 1Connell and O'Reilly Families Call Manipulation Core Facility, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

Transfusion
|June 30, 2025
PubMed
概括

在良好制造实践 (GMP) 条件下,Highway1微流体细胞分类器可靠地净化CD4 T细胞用于细胞疗法制造. 它为治疗细胞净化提供了改进的处理时间和用户友好的操作.

关键词:
血液中心运营的血液中心运营.细胞疗法是细胞疗法.输血服务业务的运营.

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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