在治疗深层流体耐火性真菌角膜炎的治疗中,静脉内安波特里辛B与伏里可纳的比较疗效
Charul Singh1, Amrita Mohanty1, Raksheeth N Rajagopal1
1Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Indian journal of ophthalmology
|June 30, 2025
概括
与内 Voriconazole (ISVCZ) 相比,内 Amphotericin B (ISAMPB) 在耐火性深层菌角膜炎中提供了更好的结果. ISAMPB显示了更高的临床解决率和减少治疗性角质形成手术的需要.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐火性深层层菌状炎在眼部感染中构成了重大挑战.
- 标准的局部和口服抗真菌药物可能不足以治疗严重病例.
研究的目的:
- 为了比较辅助剂内氨酸B (ISAMPB) 与内沃里科纳 (ISVCZ) 在治疗耐火性深层菌角膜炎的疗效.
主要方法:
- 对49名微生物学确诊的真菌角膜炎患者的回顾性审查,这些患者对初始治疗不耐药.
- 患者接受ISAMPB (5-10微克/0.1毫升) 或ISVCZ (50微克/0.1毫升) 作为辅助疗法.
- 评估的结果包括临床解决方案和治疗性角质整形的需要;用于分析的后勤回归.
主要成果:
- ISAMPB组 (34名患者) 显示53%的分辨率,其中41.1%需要治疗性角质塑性.
- 在ISVCZ组 (15名患者) 中,分辨率为10%,其中86%需要治疗性角膜整形 (P <0.01).
- 对ISAMPB反应的调整几率比为21.98 (P = 0.013),表明结果明显更好.
结论:
- 在治疗深层层流体耐火性真菌角膜炎方面,静脉内安二甲比静脉内沃里康纳更有效.
- 在这些具有挑战性的病例中,ISAMPB提供了更好的临床解决方案,并减少了角膜移植的必要性.
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