在人类婴儿时期,肠道微生物代谢和视觉神经回路的共同发展
Kevin S Bonham1,2, Emma T Margolis3, Guilherme Fahur Bottino1
1Department of Biological Sciences, Wellesley College, Wellesley, Massachusetts, USA.
mBio
|June 30, 2025
概括
早期的肠道微生物代谢影响婴儿大脑发育. 4个月的微生物基因预测到14个月的视觉皮层发育,突出了早期神经可塑性中的肠-大脑轴.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 发育生物学是发展生物学.
背景情况:
- 婴儿期对大脑和感官发育具有高度的神经可塑性.
- 肠道微生物组在生命早期发生显著变化,并可能通过神经活性化合物代谢影响大脑发育.
研究的目的:
- 调查肠道微生物代谢与婴儿视觉皮层神经发育之间的关联.
- 探索早期微生物组组成如何影响后来的大脑发育.
主要方法:
- 在18个月内对194名南非婴儿进行了长度研究.
- 对微生物基因进行分析,这些基因为神经活性化合物 (GABA,谷氨酸,酸盐,SCFA) 编码酶.
- 使用视觉唤起潜力 (VEP) 测量视觉皮层神经发育.
主要成果:
- 4个月的微生物基因组与9-14个月的VEP测量有很强的关联.
- 微生物代谢和VEP之间的潜在关联比同时存在的关联要多.
- 特定的微生物代谢途径与神经可塑性调节的视觉神经发育有关.
结论:
- 早期肠道微生物的代谢潜力在塑造神经可塑性和视觉神经发育方面发挥着至关重要的作用.
- 婴儿早期的微生物代谢可能会影响随后的神经发育.
- 肠-大脑轴是早期神经发育轨迹的一个重要因素.
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