实时选用纸喷雾化缩质谱仪进行实地应用的缩
John T Kelly1, Ashlee R Swindle1, Kyle M Samperton1
1Savannah River National Laboratory, Aiken, South Carolina 29808, United States.
Journal of the American Society for Mass Spectrometry
|June 30, 2025
概括
一种使用高分辨率质谱仪 (HRMS) 的新型纸喷电离 (PSI) 方法快速选缩. 这种技术为同位素提供了50 pg的检测极限,有助于核取证和安全措施.
科学领域:
- 分析化学 分析化学
- 核化学 核化学 核化学
- 法医科学 法医科学 法医科学
背景情况:
- 精确的缩确定对于核安全和核不扩散至关重要.
- 现有的同位素分析方法可能耗时,需要大量的样本准备.
研究的目的:
- 通过纸雾化离子化 (PSI) 和高分辨率质谱法 (HRMS) 演示缩的快速同位素比选技术.
- 为同位素分析建立一个敏感和高效的分析工作流程.
主要方法:
- 使用了一个环境电离质谱仪和一个定制的JEOL PSI附件.
- 采用最小的样本准备用于快速分析.
- 测量了样品的同位素比率,包括贫 (DU) 和低缩 (LEU).
主要成果:
- 对单个同位素 (例如235U和238U) 达到约50ppg的方法检测极限.
- 成功地区分了贫 (DU) 和低缩 (LEU) 样本.
- 证明了在现场和实验室快速查的能力.
结论:
- PSI-HRMS技术为同位素比率查提供了一种快速而敏感的方法.
- 这种工作流显示出在核取证,国际核安全保护和不扩散方面的应用具有重大前景.
- 预计进一步优化将提高同位素的敏感性.
相关概念视频
Electrospray Ionization (ESI) Mass Spectrometry
1.2K
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
1.2K
Atomic Emission Spectroscopy: Lab
251
AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
251
Atomic Emission Spectroscopy: Instrumentation
615
The instrumentation of atomic emission spectrometry (AES) involves various components, including atomization devices that convert samples into gas-phase atoms and ions. There are two main types of atomization devices: continuous and discrete atomizers. Continuous atomizers, like plasmas and flames, introduce samples in a constant stream, while discrete atomizers inject individual samples using syringes or autosamplers. The most common discrete atomizer is the electrothermal atomizer.
615
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview
957
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
957
Atomic Emission Spectroscopy: Overview
2.6K
Atomic emission spectroscopy (AES) is an analytical technique used to determine the elemental composition of a sample by analyzing the light emitted from excited atoms. In AES, atoms in a sample are excited to higher energy levels by thermal energy from high-temperature sources, such as plasma, arcs, or sparks. When these excited atoms return to lower energy states, they emit light at specific wavelengths characteristic of each element. The resulting atomic emission spectrum, which consists of...
2.6K
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle
891
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
891


