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怀孕期间的上皮上腺癌
Marta Klepinowska1, Elżbieta Sowińska-Przepiera2, Elżbieta Andrysiak-Mamos2
1Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University Hospital No. 1, Szczecin, Poland, Szczecin, Poland. martaklepinowska@pum.edu.pl.
怀孕期间的上皮上腺癌 (ACC) 很少见,但由于症状与正常怀孕重叠,需要保持警. 早期诊断和量身定制的治疗对母亲和孩子都至关重要,尽管治疗选择仍然有限.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 产科和妇科 产科和妇科
背景情况:
- 皮上腺癌 (ACC) 是一种罕见的恶性瘤.
- 在ACC中,高皮质醇症可以模仿正常的怀孕症状,可能延迟诊断.
- ACC和怀孕同时发生是非常罕见的.
研究的目的:
- 为了突出怀孕期间ACC的诊断挑战.
- 根据欧洲和波兰的指导方针,审查当前的治疗建议.
- 介绍一个案例研究,说明在怀孕期间管理ACC的复杂性.
主要方法:
- 在PubMed上系统地搜索文献,使用关键词"上腺皮质癌"",ACC"和"怀孕".
- 分析了怀孕期间诊断的12例报告的ACC病例,包括作者机构的一例.
- 对母亲和儿童的诊断标准,管理策略和结果的审查.
主要成果:
- 一名29岁的孕妇在怀孕20/21周被诊断患有ACC,接受了手术.
- 辅助治疗推迟到怀孕32周;由于胎儿痛苦,在31周通过剖腹产分娩.
- 观察到产后ACC复发,尽管接受了治疗,但患者在诊断后14个月死亡.
结论:
- 在怀孕期间提高对ACC的警至关重要,认识到孕妇的荷尔蒙测试差异.
- 在怀孕期间,高水平的自由血皮质醇和尿液自由皮质醇 (UFC) 是正常的,这复杂化了ACC诊断.
- 孕期ACC的有限治疗选择带来了重大的伦理挑战.
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