怀孕妇女甲状腺激素的参考间隔
Tao Sun1, Xiaoya Liu1, Chenghong Yin2,3
1Beijing Obstetrics and Gynaecology Hospital, Capital Medical University, Beijing, China.
Endokrynologia Polska
|June 30, 2025
概括
对于孕妇来说,确定三个月特定的甲状腺功能范围至关重要. 这些新的范围不同于标准指南,有助于准确诊断和预防怀孕期间甲状腺疾病的误诊.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 临床化学 临床化学
背景情况:
- 确定甲状腺功能的三个月具体参考范围对于准确的临床评估在孕妇人群中至关重要.
- 现有的标准甲状腺功能范围可能不准确地反映怀孕期间的生理变化.
研究的目的:
- 在北京的孕妇中建立甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的三个月具体参考范围.
- 为了比较这些怀孕特定的范围与既定的准则,并评估它们对甲状腺疾病诊断的影响.
主要方法:
- 一组361名健康的孕妇和122名非孕妇接受了甲状腺功能测试 (TSH,FT4).
- 参考范围是根据每个三个月的数据的第2.5个百分点和第97.5个百分点确定的.
- 甲状腺功能的评估是使用已建立的妊娠特定参考范围进行的.
主要成果:
- 为TSH和FT4建立了季度特定的参考范围:TSH (第一:0.02-3.39,第二:0.03-3.43,第三:0.27-3.88 mIU/L);FT4 (第一:12.24-20.77,第二:10.78-20.75,第三:9.54-16.02 pmol/L).
- 在整个怀孕期间,血清TSH和FT4水平之间观察到微弱的负相关性.
- 确定了亚临床甲状腺功能障碍症 (3.5%),甲状腺功能障碍症 (0%),亚临床甲状腺功能障碍症 (2.5%) 和甲状腺功能障碍症 (0.3%) 的患病率.
结论:
- 孕期特定的甲状腺功能参考范围与美国甲状腺协会 (ATA) 推的范围有很大不同.
- 实施这些量身定制的范围对于准确诊断和管理孕妇甲状腺疾病至关重要.
- 临床采用这些范围可以帮助避免过度诊断和怀孕期间甲状腺疾病的错误诊断.
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