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Updated: Sep 17, 2025

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases
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A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases

Published on: December 23, 2013

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含有3'-5'外核酶域的DinG的结构和功能研究

Tianwen Gao1, Wanshan Hao1, Jin Gao1

  • 1Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, China.

mBio
|June 30, 2025
PubMed
概括

黄金葡萄球菌 (Staphylococcus aureus DinG) (SaDinG) 是一种独特的酶,具有酶和外核酶活动,对于修复DNA交叉链路至关重要. 它的双重功能由ATP水平调节,对细菌的生存至关重要.

关键词:
在 DinG DinG 中.货币市场中心MMC异核酶是外核酶的一种.螺旋酸的使用方法蛋白质结构 蛋白质结构

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Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis11:08

Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

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Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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