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Updated: Sep 17, 2025

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在塑性聚乙烯 (PVC) 表面上对胰岛素阿斯巴特吸附的粗粒度洞察力

Meriem Sahnoune Millot1, Julien Devémy1, Philip Chennell2

  • 1Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut de Chimie de Clermont-Ferrand, Clermont-Ferrand F-63000, France.

The journal of physical chemistry. B
|June 30, 2025
PubMed
概括

胰岛素亚斯巴特吸附于医疗管道中的聚乙烯 (PVC) 基质,而不是增塑剂. 分子动力学模拟解释了为什么塑化和非塑化PVC在糖尿病治疗期间表现出类似的胰岛素损失.

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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