在"既定"和"非标签"冠状动脉病变中吸收®生物可吸收支架:来自GABI-R®注册表的5年数据
Aydin Huseynov1,2, Michael Behnes3,4, Holger Nef5,6
1First Department of Medicine-Cardiology, Faculty of Medicine Mannheim, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. a.n.huseynov@gmail.com.
概括
非标签使用的可生物吸收支架 (BRS) 显示了更高的短期支架血栓形成和长期不良事件. 长期随访显示,非标签和批准的BRS适应症之间的支架血栓形成没有显著差异.
科学领域:
- 心血管医学 心血管医学
- 医疗器械 医疗器械 医疗器械
- 干预性心脏病学 干预性心脏病学
背景情况:
- 对生物吸收性支架的长期评估至关重要.
- 对于非标签性指示的生物吸收性支架 (BRS) 植入的真实世界数据提供了宝贵的临床见解.
研究的目的:
- 提供长期跟踪数据,以了解生物吸收性支架 (BRS) 在非标签和已批准的适用情况中的使用情况.
主要方法:
- 德国-奥地利的ABSORB-RegIstRy (GABI-R) 评估了ABSORB everolimus-eluting poly-L-乳酸基生物可吸收支架系统的五年结果.
- 分析了来自3082名患者 (2013-2016) 的前性,非干预性,多中心数据,并进行了中央,独立的数据处理和跟踪.
主要成果:
- 非标签的BRS使用 (75.2%的患者) 与ST升高心肌梗塞 (STEMI) 和复杂冠状动脉疾病的更高率有关.
- 没有标签的症状的患者在30天后出现显著更高的支架血栓形成率 (1.08%对比0.26%) 和目标血管衰竭 (TVF) 在6个月后 (4.62%对比2.61%).
结论:
- 非标签的BRS使用与短期支架血栓形成和长期主要心血管不良事件 (MACE) 的增加有关,这是由于更复杂的病变和更高的发病率.
- 然而,长期分析表明,在非标签和批准的BRS适应症之间,支架血栓形成没有显著差异.
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