在脊髓内转移中,除了外科手术的激进性之外:神经功能和系统性疾病负担推动了患者的结果
Meltem Ivren1, Dilber Yalman1, Basem Ishak1,2
1Department of Neurosurgery, Heidelberg University, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Journal of neuro-oncology
|June 30, 2025
概括
脊髓内转移 (ISCM) 的手术治疗是安全的,可以保持神经功能. 虽然总切除显示早期死亡率较低,但患者选择和系统性疾病负担是关键的预后因素.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 脊柱外科手术 脊柱外科手术
背景情况:
- 脊髓内转移 (ISCM) 是一种罕见且具有挑战性的病变.
- 最佳的手术管理,包括切除程度 (EOR),仍然存在争议.
- 对于ISCM治疗,有有限的基于证据的指导.
研究的目的:
- 为了评估外科手术治疗ISCM患者的术后结果,神经功能和短期存活率.
- 根据不同的外科手术范围来比较结果:只有活检,亚总切除和总体切除 (GTR).
- 确定影响ISCM生存和神经恢复的预后因素.
主要方法:
- 对16名为ISCM手术治疗的患者进行了回顾性单中心研究 (2015-2024).
- 根据手术程度分层的患者 (活检,亚总或全切除).
- 评估结果包括术后并发症,神经功能和90天生存期;还进行了文献综述.
主要成果:
- 包括16名患者 (平均年龄59岁,56%男性) 主要患有胸部ISCM.
- 19%的患者出现了手术并发症,没有不可逆转的神经损伤或手术内死亡.
- 总切除 (GTR) 显示了较低的早期死亡率 (13%) 与分总 (60%) 或仅活检 (33%) 相比 (p=0.015),但EOR不是生存的独立预测指标 (p=0.834).
- 在所有患者中,无论切除程度如何,神经功能都保持稳定或改善.
结论:
- 通过手术治疗ISCM是安全的,神经疾病的发病率最小,并有可能稳定或改善症状.
- 虽然GTR与更好的短期生存相关,但系统性疾病负担和术后神经状态是更重要的预后指标.
- 手术决策应优先考虑功能维护和根据整体健康状况和疾病程度进行仔细的患者选择.
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