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精子异常:微RNAs的差异表达

Sara Rahbar¹, Behnaz Sadeghzadeh Oskouei^1,2, Nahid Azad³

¹Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of assisted reproduction and genetics

|June 30, 2025

概括

微RNAs (miRNAs) 通过调节精子生成,对男性生育至关重要. 这些小分子的失调会导致男性不育,突出显示它们作为诊断和治疗点的潜力.

科学领域:

生殖生物学生殖生物学
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

精子发生,即持续生产精子,对于成年男性的生育能力至关重要,并依赖精子干细胞 (SSC) 的精确调节.
微RNAs (miRNAs) 是基因表达的关键转录后调节者,影响人类和动物的各种生物途径.
在有精子疾病的男性中观察到异常miRNA表达,这表明在男性不孕症的发病过程中发挥了作用.

研究的目的:

阐明miRNA失调导致男性不孕症的机制.
探索miRNAs作为诊断生物标志物和治疗男性生殖障碍的治疗点的潜力.

主要方法:

本综述综合了目前关于精子生成和男性不孕症中miRNA功能的研究.
它分析了调查与精子疾病有关的差异性miRNA表达的研究.
讨论了关于miRNA参与男性生殖健康的机制性见解.

主要成果:

塞尔托利和生殖细胞中的miRNAs调节基因表达,以支持精子生成.
在有和没有精子疾病的男性之间存在不同的miRNA配置文件.
有证据表明miRNA失调与男性不孕症的发病有关.

结论:

miRNA失调在男性不孕症的发展中起着重要作用.
向miRNAs为诊断和治疗男性生殖条件提供了有希望的途径.

关键词:

动物精子缺血症 (Asthenozoospermia) 是一个疾病.这就是米RNAs.橄动物精子缺陷症 (Oligozoospermia)精子精子精子甲动物精子症 (teratozoospermia) 是一种

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...