基于社区的队列中的COVID-19和认知变化
Ryan T Demmer1,2,3, Talea Cornelius4, Zarina Kraal5
1Division of Epidemiology, Department of Quantitative Health Sciences, College of Medicine and Science, Mayo Clinic, Rochester, Minnesota.
JAMA network open
|June 30, 2025
概括
感染SARS-CoV-2可以加速认知能力下降,特别是在患有病毒的住院老年人中. 与未感染个体相比,非住院感染者没有表现出这种加速的认知障碍.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 老年学是一门学科.
背景情况:
- 感染SARS-CoV-2 (导致COVID-19的病毒) 与神经效应和认知缺陷有关.
- 了解SARS-CoV-2对认知功能的长期影响至关重要,特别是在老年人群中.
研究的目的:
- 为了调查SARS-CoV-2感染是否与没有感染的个人相比加速认知衰退.
- 根据SARS-CoV-2感染后住院状态区分认知影响.
主要方法:
- 一个多中心的前性队列研究,涉及来自ARIC和CCoRPS研究的3525名参与者.
- 认知功能在流行前和流行期间被评估,SARS-CoV-2感染状况由各种诊断标志物确定.
- 神经心理测试评估了多个认知领域,确认因素分析产生了全球认知功能得分.
主要成果:
- 在3525名老年参与者中 (平均年龄为80.8岁),307人 (8.7%) 感染了SARS-CoV-2.
- 与未感染个体相比,因SARS-CoV-2感染住院的参与者表现出加速的认知衰退 (β = -0.06).
- 在非住院的SARS-CoV-2感染者中没有观察到认知衰退的显著加速.
结论:
- 由于SARS-CoV-2感染而入院与老年人加速认知衰退有关.
- 认知影响,特别是对记忆和执行功能的影响,与严重的 (住院) SARS-CoV-2 感染有关.
- 非住院的SARS-CoV-2感染在这个队列中没有显示出认知衰退的显著加速.
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