洛伦德拉斯塔特在患有无控高血压和耐治疗高血压的参与者中:启动HTN随机临床试验
在PubMed上查看摘要
概括
此摘要是机器生成的。在未控制高血压的成年人中,包括治疗耐药的病例中,洛伦多斯塔特有效降低了血压. 这种阿尔多合成酶抑制剂在3期试验中显示出显著的疗效和可控的安全性.
科学领域
- 心血管医学
- 药理学
- 肝脏病学
背景情况
- 失控的高血压是一个重要的全球健康问题,其中失调的阿尔多激素产生起着关键作用.
- 通过向阿尔多合成,阿尔多合成抑制剂为治疗高血压提供了潜在的治疗途径.
研究的目的
- 评估洛伦多斯塔特降低非控制和耐治疗高血压的成年人血压的疗效和安全性.
- 评估洛伦多斯塔特在加入现有抗高血压药物治疗方案时的效果.
主要方法
- 这是一项3期随机临床试验,涉及13个国家的1083名未经控制的高血压成年人.
- 参与者每天服用洛伦德罗斯塔特 (50 毫克或升至 100 毫克) 或安慰剂,持续 12 周.
- 与安慰剂相比,主要结论是第6周自动化静脉血压的变化.
主要成果
- 与安慰剂相比,联合50毫克洛隆德拉斯塔特组在第6周显著降低了静脉压 (-16. 9毫米升) (- 7. 9毫米升) (差异为- 9. 1毫米升,P<. 001).
- 特别有趣的不良事件,包括低血,高血和功能下降,在洛伦德罗斯塔特治疗中更为频繁,但通常导致治疗中断率较低.
- 治疗引起的不良事件大多为轻度至中度.
结论
- 洛伦多斯塔特在不控制高血压的成年人,包括耐治疗高血压的患者中显示出降低血压的效果.
- 洛伦多斯塔特的安全性概况是可控的,不良反应通常为轻度至中度,很少导致停药.
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