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Updated: Sep 17, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
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间歇性缺氧通过NLRP3 / IL-1β依赖性热死,由HIF-1α信号通路介导,加剧了喘炎症

Ling Zhou1, Huojun Zhang2, Lu Liu3

  • 1Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Chinese medical journal
|June 30, 2025
PubMed
概括

间歇性缺氧通过激活HIF-1α/NLRP3/IL-1β通路而加剧喘,导致热和中性粒细胞炎症. 针对这种途径为患有阻塞性睡眠呼吸暂停-呼吸暂停综合征的喘患者提供了潜在的治疗方法.

关键词:
喘 喘 是一种低氧诱导因子-1α (HIF-1α)炎症 炎症是一种炎症.互乐金-1β是其中的一种.间歇性缺氧 间歇性缺氧含有NOD类受体皮林域的蛋白3 (NLRP3)

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