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来自Asplenium dalhousiae的银纳米颗粒的生物合成和表征及其潜在的生物特性

Shafia Parveen¹, Shazia Iqbal², Saima Maher¹

¹Department of Chemistry, Sardar Bahadur Khan Women University Quetta, Quetta, Pakistan.

|June 30, 2025

概括

使用Asplenium dalhousiae的银纳米粒子 (AgNPs) 的绿色合成显示出显著的抗菌,抗氧化和抗癌特性. n-hexane提取物产生了AgNP,它们对大肠杆菌,B. subtilis和P. aeruginosa具有强大的活性.

科学领域:

纳米技术纳米技术
绿色化学绿色化学
药用植物研究药用植物研究

背景情况:

药用植物是用于纳米粒子合成的生物活性化合物的丰富来源.
银纳米粒子 (AgNPs) 具有多种生物医学应用.
Asplenium dalhousiae是一种药用植物,具有潜在的治疗特性.

研究的目的:

为了研究使用阿斯普莱尼姆dalhousiae提取物AgNP的绿色合成.
描述合成的AgNP并评估它们的生物活动.
探索AgNP作为环保治疗剂的潜力.

主要方法:

绿色合成AgNP使用水性,和n-hexane提取物的阿斯普莱尼姆dalhousiae.
使用紫外可见光谱,FTIR,SEM和XRD进行表征.
对大肠杆菌,B. subtilis和P. aeruginosa的抗菌活性的评估.
对α-氨酶抑制,抗氧化活性 (DPPH测定) 和对A2780细胞的细胞毒性活性的评估.

主要成果:

紫外线光谱学证实了AgNP的合成,具有特征性的吸收峰值.
FTIR分析确定了负责减少的功能组.
SEM和XRD揭示了球形,结晶的AgNP,平均直径为46.98nm.
从n-hexane提取物合成的AgNP显示出最高的抗菌活性.
观察到显著的α-氨基酶抑制 (85.04%) 和抗氧化活性.
水性和n-hexane AgNPs对A2780细胞表现出强烈的细胞毒性活性 (IC50值分别为15.76和9.11μg/ml).

结论:

阿斯普莱尼乌姆dalhousiae是AgNP合成的有效绿色前体.
合成的AgNP具有显著的抗菌,α-氨基酶抑制,抗氧化和抗癌特性.
这项研究提出了一种新的,环保的方法,用于开发生物医学应用的向纳米疗法.

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