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基于发病时间的新生儿COVID-19临床特征的比较
Ting Yang1, Rui Li2, You Chen1
1Department of Neonatology, Baoan Women's and Children's Hospital, Shenzhen, China.
Medicine
|June 30, 2025
概括
新生儿冠状病毒病19 (COVID-19) 发病时间影响临床表现. 新生儿早期出现的COVID-19往往无症状,而晚期出现的病例显示出更多的发烧和呼吸道症状.
科学领域:
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 新生儿败血症的临床特征因发病时间而异.
- 基于发病时间的新生儿冠状病毒病19 (COVID-19) 的临床过程尚不清楚.
研究的目的:
- 基于早期与晚期发病的新生儿COVID-19的临床特征进行比较.
- 确定COVID-19新生儿早期发病组 (EOG) 和晚期发病组 (LOG) 之间的症状,严重程度和结果的差异.
主要方法:
- 从2022年12月14日至2023年1月9日期间诊断出COVID-19的212名新生儿的临床数据的回顾性分析.
- 病例被分为EOG (5天内发病) 和LOG (5天后发病).
- 在EOG和LOG之间比较临床表现,实验室发现和治疗结果.
主要成果:
- 在212名新生儿中,36名在EOG,176名在LOG. 欧洲人群有较高的无症状病例比例 (44.4%与2.3%相比).
- 与EOG相比,LOG的发烧 (93.8%),咳 (43.8%) 和食欲不佳 (70.5%) 的流行率和持续时间更高.
- 肺炎在LOG中更常见 (96.8%),虽然大多数病例是轻微的,但LOG中中度或重度疾病的百分比更高.
结论:
- 新生儿COVID-19呈现因发病时间不同而有显著差异.
- 早期出现的COVID-19往往无症状,而晚发病例更容易出现症状性疾病,包括发烧和呼吸系统问题.
- 尽管症状的变化,新生儿COVID-19通常具有良好的预后与症状治疗.
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