开发和验证一个动态的诺姆图谱预测肠道营养在严重创伤性脑损伤患者的食不耐受:一个外部验证研究研究
Yibo Pan1,2, Chen Min1, Jing Li1
1Department of Coronary Care Unit, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Medicine
|June 30, 2025
概括
这项研究开发了一种动态诺米图,用于预测严重创伤性脑损伤 (STBI) 患者的肠道营养食不耐受 (ENFI). 使用这种模型进行早期风险评估可以预防ENFI并改善患者的治疗结果.
科学领域:
- 关键护理医学 关键护理医学
- 神经外科 神经外科
- 临床营养学 临床营养学
背景情况:
- 严重创伤性脑损伤 (STBI) 患者经常经历肠道营养食不耐受 (ENFI).
- ENFI使治疗复杂化,延长住院时间,并增加STBI患者的感染风险.
- 有效预测和管理ENFI对于优化对这一群体的护理至关重要.
研究的目的:
- 开发和验证一个动态风险预测模型,用于在STBI患者中预测ENFI的风险.
- 在这个群体中确定ENFI的独立预测因子.
- 为早期识别和预防ENFI提供一个工具.
主要方法:
- 使用电子病历进行的回顾性队列研究 (2019年1月 - 2023年7月).
- 从符合条件的STBI患者组成的开发和验证队列.
- 使用R软件构建和验证的动态名图.
主要成果:
- 总共有409名STBI患者被纳入 (302名发展,107名验证).
- 在发展阶段,ENFI的发病率为50.7%,在验证阶段为56.1%.
- 平均动脉压,机械通风,摄入/输出平衡和联合抗生素是ENFI的独立预测因素.
结论:
- 一个经过验证的动态名录图准确地预测了STBI患者的ENFI风险.
- 该模型证明了早期风险评估的良好校准和临床实用性.
- 这种工具可以帮助重症监护室工作人员预防ENFI并改善临床结果.
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