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致病原体分布和抗生素敏感性分析与尿路结石相关的泌尿毒症:一项回顾性观察性研究
Yudong Hu1, Xiaofeng Wang, Yujie Chen
1Department of Urology, The Thirteenth People's Hospital, Chongqing City, China.
Medicine
|June 30, 2025
概括
尿路结石的泌尿失调患者如果是女性或糖尿病患者,则更有可能有积极的培养. 格拉姆阴性细菌,主要是大肠杆菌,很常见,卡巴胺具有很高的敏感性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 医学微生物学 医学微生物学
背景情况:
- 尿路感染,一种严重的尿路感染,正在增加.
- 与尿路结石相关的尿液的病原体通常是复杂的和抗生素耐药的.
- 经验性抗生素治疗尿道的治疗可能并不总是有效的.
研究的目的:
- 分析致病性细菌在尿路结石的泌尿突发症中的分布.
- 为了确定这些病原体的抗生素敏感性模式.
- 确定与积极培养相关的临床特征.
主要方法:
- 从一个单一中心回顾收集病例数据 (2015年7月 - 2025年2月).
- 对临床特征的分析,比较培养阳性和培养阴性组.
- 检查细菌分布和抗生素敏感率.
主要成果:
- 分析了64名患者,62.5%的尿液培养为阳性.
- 女性患者和糖尿病患者的阳性培养率较高 (P=.012,P=.003).
- 格拉姆阴性细菌 (66%) 主导,大肠杆菌 (50%) 最常见. 大肠杆菌对tigecycline,nitrofurantoin和carbapenems具有很高的敏感性. 百分之十六的Enterococcus faecium对万科米辛和达普托米辛敏感.
结论:
- 妇女和糖尿病患者在与尿路结石相关的尿路结石症中更容易产生阳性尿液培养.
- 格拉姆阴性细菌,特别是大肠杆菌,是主要的病原体.
- 在这个队列中,卡巴因表现出高的总体易感性对格拉姆阴性细菌.
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