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Updated: Sep 17, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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球状蛋白折叠的形进化是从随机序列的随机序列开始的

Harutyun Sahakyan1, Sanasar G Babajanyan1, Yuri I Wolf1

  • 1Computational Biology Branch, Division of Intramural Research, National Library of Medicine, NIH, Bethesda, MD 20894.

Proceedings of the National Academy of Sciences of the United States of America
|June 30, 2025
PubMed
概括

蛋白质折叠进化模拟器 (PFES) 模拟了蛋白质折叠如何从随机序列进化. 稳定的蛋白质折叠可以相对快速出现,这表明进化道路比以前认为的更容易.

关键词:
折叠核化的核化分子动力学分子动力学蛋白质的进化 蛋白质的进化蛋白质折叠是蛋白质的折叠.蛋白质结构预测 蛋白质结构预测

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