如何扩大对新方法方法 (NAM) 的认识,考虑和采用
Oluwakemi Oyetade1, David G Allen1,2, Jessie Carder3
1Inotiv, RTP, NC, USA.
ALTEX
|June 30, 2025
概括
新方法方法 (NAMs) 为动物进行化学安全测试提供了替代方案. 利益相关者讨论确定了NAM采用的关键障碍,包括认知,监管和成本,并提出了更广泛实施的解决方案.
科学领域:
- 毒理学和化学安全
- 监管科学 监管科学
- 动物福利和替代方法
背景情况:
- 新方法方法 (NAM) 越来越多地用于化学危害和风险评估,旨在取代,减少或完善动物试验.
- 尽管NAM的发展有所增加,但监管采用和对NAM的普遍认识仍然很低.
- 考虑替代方法工作组 (CAMWG) 调查了利益相关者对NAM的观点.
研究的目的:
- 了解各种利益相关者如何考虑和利用毒理学和研究中的NAM.
- 确定阻碍在监管和科学实践中更广泛地采用NAM的障碍.
- 提出可行的解决方案来克服这些障碍,并鼓励实施NAM.
主要方法:
- 制定了一系列专注的问题,以指导与利益相关方的讨论.
- CAMWG成员与来自农业化学,工业化学,消费品和制药行业,学术界和动物护理委员会等不同部门的代表进行了接触.
- 收集了利益相关方关于考虑传统动物试验的替代方法的观点.
主要成果:
- 所有受访的利益相关者目前都在不同程度上使用或考虑使用NAM.
- 确定了NAM采用更广泛的五个主要障碍:感知,监管接受,科学/技术限制,教育和财务考虑.
- 提出的解决方案包括定制教育,加强协作,改善沟通,确保适合目的的NAM使用,协调的接受标准和更好的信息存储库.
结论:
- 通过有针对性的战略解决已识别的障碍对于提高NAM的认识,考虑和采用至关重要.
- 建议积极协作,明确沟通,并为NAM信息建立一个中央存储库.
- 成功扩展NAM需要共同努力,克服现有的挑战,并证明其在化学安全评估中的价值.
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