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通过数字糖尿病日志改善血糖控制:随机对照试验的二次分析,通过观察,现实世界的数据进行丰富
Dominic Ehrmann1,2, Bernhard Ruch3,4, Michael Mitter3,4
1Research Institute of the Diabetes Academy Mergentheim, Forschungsinstitut der Diabetes-Akademie Bad Mergentheim, Bad Mergentheim, Germany.
Journal of medical Internet research
|June 30, 2025
概括
使用数字糖尿病日志在3个月内实现最佳血糖控制 (HbA1c ≤6.5%) 的机会几乎翻了一番. 现实数据还显示,糖尿病患者的平均血糖水平长期显著降低.
科学领域:
- 内分泌学 在内分泌学.
- 数字健康数字健康
- 糖尿病管理 糖尿病管理
背景情况:
- 糖尿病自我管理对于治疗成功至关重要.
- 数字工具有潜力减轻自我管理负担并改善血糖控制.
研究的目的:
- 评估数字糖尿病日志 (mySugr) 是否增加了在3个月内实现最佳血糖控制 (HbA1c ≤6.5%) 的可能性.
- 评估日志对3个月和12个月的平均血糖水平的长期影响,使用现实数据 (RWD).
主要方法:
- 对342名参与者的随机对照试验 (RCT) 数据的二次分析.
- 使用后勤回归来确定在3个月内达到HbA1c ≤6.5%的可能性.
- 倾向性得分匹配用于2861名参与者的RWD分析,以评估3个月和12个月的平均血糖变化.
主要成果:
- 随机试验数据显示,干预组中实现最佳血糖控制的可能性几乎翻了一番 (OR 2.24,P=.02).
- 在3个月后,RWD显示了1型 (-16.3 mg/dL) 和2型 (-27.3 mg/dL) 糖尿病的平均血糖显著降低.
- 在基线HbA1c>8.5%的参与者中观察到最大的减少. 在12个月 (-19.8毫克/分升) 后,平均血糖持续下降.
结论:
- mySugr日志显著增加了在3个月内实现最佳血糖控制的可能性.
- 现实世界的数据证实了日志使用的平均血糖水平的显著和持续降低,特别是在基线HbA1c较高的人群中.
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