探索越南患者多敏化和过敏性鼻炎亚型之间的联系
Thien Tai Tran1,2, Tu H K Trinh3, Duy L Pham4
1Department of Allergy and Clinical Immunology, Hanoi Medical University, Ha Noi, Vietnam.
International archives of allergy and immunology
|June 30, 2025
概括
越南过敏性鼻炎 (AR) 患者中多敏感性是常见的,通常与严重的症状和室内灰尘虫过敏有关. 了解这些配置文件是个性化AR管理的关键.
科学领域:
- 临床免疫学临床免疫学
- 过敏学 过敏学
- 流行病学 流行病学
背景情况:
- 过敏性鼻炎 (AR) 经常与对多种过敏原 (多敏感性) 的敏感化有关.
- 了解越南等不同人口中的AR表型和敏感化模式,对于有效管理至关重要.
研究的目的:
- 调查越南AR患者的人口和临床特征.
- 确定过敏敏感化概况及其与AR表型的关联.
- 要区分非过敏性鼻炎 (NAR),单敏性和多敏性AR患者.
主要方法:
- 这是一项多中心的,涉及越南胡志明市146名参与者的横截面研究.
- 评估包括AR状态,视觉模拟尺度 (VAS) 评分,皮肤刺伤测试 (SPT) 和总和特定IgE的血液测试.
- 患者根据对空气过敏原的敏感性进行分类,多敏感性定义为对≥2种过敏原类别的反应性.
主要成果:
- 在AR患者中,多敏化 (42.47%) 和单敏化 (41.78%) 是普遍存在的,非过敏性鼻炎 (NAR) 在15.75%.
- 与NAR相比,敏感的患者在发病时表现出更年轻的年龄,更长的疾病持续时间,更频繁的口服皮质类固醇使用,以及较高的VAS得分.
- 家庭灰尘虫敏感性是最常见的;多敏感性与中度至重度的AR相关,而NAR与轻度间歇性AR相关.
结论:
- 在NAR,单敏感和多敏感的AR患者之间存在显著的临床和免疫学区别.
- 调查结果强调,需要根据个别的敏感性概况和AR表型制定量身定制的管理策略.
- 这项研究为越南人口中AR特征提供了有价值的见解.
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