抗emetics的协会使用与事件慢性病
Diana S Kalantar1, Rina Takahashi2, Jenny I Shen3
1Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension and Kidney Transplantation, University of California, Irvine, California; Long Beach VA Medical Center, Long Beach, California.
概括
抗药的使用与以前没有脏问题的患者患慢性脏病 (CKD) 的风险更高. 建议对那些被处方的抗药物进行仔细的功能监测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道症状显著影响患者的营养.
- 抗药对于控制这些症状和维持营养状况至关重要.
- 抗药对功能的长期影响尚不清楚.
研究的目的:
- 调查抗药使用与慢性病 (CKD) 发病率之间的关联.
- 为了评估这一关联在一组美国退伍军人最初正常的功能.
主要方法:
- 一项历史上的队列研究,对323,970名美国退伍军人进行了正常估计的淋巴球过率 (eGFR) 的研究.
- 确定了13,154名退伍军人开始服用抗药.
- 利用考克斯的比例危险模型,倾向得分匹配和重叠权重来分析抗药和发生的CKD之间的关系 (eGFR <60 mL/min/1.73 m2).
主要成果:
- 消药使用者更有可能是女性,吸烟者,并具有更高的并发症患病率.
- 在各种分析模型 (HRs从1.22到1.28) 中,抗药的使用显示出与发生性CKD风险增加的一致关联.
结论:
- 抗药的使用与在没有先前存在的病的个体中发展事件CKD的风险更高有关.
- 这种关联在不同的分析方法中是强大的.
- 强调需要对处方抗emetics的患者进行警的功能监测,尽管这些药物在控制胃肠道症状方面很重要.
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