从自然到医学:以牛粘液为基础的功能辅助剂,用于口服剂型
Marta Cabibbo1, Cinzia Scialabba1, Salvatore Emanuele Drago1
1Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy.
International journal of pharmaceutics
|June 30, 2025
概括
这项研究开发了从牛粘液,pectin和粉中开发的新型微粒粉,用于口服药物输送. 这些生物相容粉末由于其抗氧化和抗炎性质,有望治疗胃肠道炎症疾病.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 制药技术 制药技术 制药技术
背景情况:
- 牛粘液 (Helix Aspersa Muller) 已被认为有助于伤口愈合,但对于胃肠道炎症尚未得到充分研究.
- 开发用于胃肠道治疗的有效口服剂型需要创新的辅助剂.
研究的目的:
- 创建和表征基于微粒的粉末从牛的粘液,点和粉作为口服配方的功能辅助剂.
- 评估这些新型粉末的抗氧化,抗炎和细胞毒性质.
主要方法:
- 喷雾干燥 (SD) 用于在两个配方 (SS_SD_40和SS_SD_20) 中将牛的粘液与点和粉结合起来.
- 分析了粉末的特性,包括产量,颗粒大小,流动性和含水量.
- 高性能液体染色学 (HPLC) 证实了艾伦的保存.
- 在体外测试中评估了抗氧化活性 (激素清除),抗炎作用 (BSA变性) 和细胞毒性 (Caco-2细胞),包括细胞因子分泌 (IL-6,IL-8).
主要成果:
- 喷雾干燥显著提高了产量 (高达50%),并产生了微粒 (7.569.70微米).
- 艾兰托因的回收率超过94%,粉末具有良好的流动性和粘粘性.
- SS_SD_20显示出优异的抗氧化活性,而SS_SD_40显示出更强的抗炎作用.
- 这两种配方均非细胞毒性,并减少了促炎性细胞因子分泌 (IL-6,IL-8).
结论:
- 牛粘液,pectin和粉协同形成多功能,生物相容的微粒粉.
- 这些粉末是针对胃肠道炎症疾病的口服配方的合适功能辅助剂.
- 开发的材料为利用牛粘液在胃肠病学中的治疗潜力提供了一种新的方法.
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