癌症模型的3D生物打印:在药物发现和开发中的游戏变革
Matylda Kurzątkowska1, Joachim Frankowski1, Marcin Sobczak1
1Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
International journal of pharmaceutics
|June 30, 2025
概括
目前癌症临床前模型的局限性阻碍了药物开发. 三维 (3D) 生物打印为创建先进的癌症模型提供了有希望的解决方案,提高了药物查准确性和个性化治疗潜力.
科学领域:
- 在瘤学瘤学.
- 生物技术是生物技术.
- 药物发现 药物发现 药物发现
背景情况:
- 目前的临床前癌症模型 (体外,体内,动物模型) 面临重大局限性,包括影响人类试验可预测性的物种间药物代谢差异.
- 这些局限性导致新化学实体在药物开发中的高失败率,导致资源浪费和时间延长.
- 改善临床前模型的迫切需要是由高癌症死亡率和发病率驱动的.
研究的目的:
- 审查3D生物打印在开发先进的临床前癌症模型中的最新应用.
- 突出3D生物打印在个性化治疗,增强疾病预测和成功的药物查方面的潜力.
- 为癌症研究中的3D生物打印技术提供全面的概述,用于药物发现和开发.
主要方法:
- 利用患者衍生或商业癌细胞来创建用于3D生物打印的生物墨水.
- 采用3D生物打印技术制造各种癌症和瘤模型.
- 审查关于这些3D生物打印模型在药物发现和开发中的应用的文献.
主要成果:
- 3D生物打印的癌症模型显示了个性化治疗的潜力,并提高了预测准确度.
- 与传统模型相比,该技术在药物查中提供了更高的成功率.
- 3D生物打印被强调为一种负担得起,灵活和高度可复制的癌症模型创建方法.
结论:
- 3D生物打印代表了临床前癌症建模中药物发现的重大进步.
- 这些先进的模型可以克服传统方法的局限性,提高药物开发的效率和成功.
- 3D生物打印的应用有望为更准确和个性化的癌症治疗提供希望.
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