暴露于per-和多醇基物质对功能障碍的影响:将流行病学证据与机械学见解整合起来
Weitao Su1, Ziwen An2, Yayuan Mei3
1Central Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, 362000, China.
Environmental pollution (Barking, Essex : 1987)
|June 30, 2025
概括
环境中暴露于 perfluoroalkyl和 polyfluoroalkyl物质 (PFAS),特别是 perfluorooctanesulfonic acid (PFOS),与功能障碍有关. 炎症和脂质代谢中断是关键的潜在机制,突出了针对性预防策略的需要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 功能障碍是全球重要的健康问题.
- 环境污染物的影响,如和多基物质 (PFAS),对脏健康的研究不足.
- 了解将PFAS暴露与功能障碍联系在一起的机制对于公共卫生至关重要.
研究的目的:
- 调查成年人血PFAS度与功能标志物之间的关联.
- 探索潜在的机制,包括炎症和分子途径,将PFAS暴露与功能障碍联系起来.
- 评估脏生物标志物对PFAS暴露的预测能力.
主要方法:
- 在中国北部对2801名成年人进行的横截面研究.
- 使用超高性能液体染色学-并联质谱法对21种PFAS进行量化.
- 评估功能和炎症标志物,通过统计分析,包括多变量回归,量子g计算,调解和生物信息学.
主要成果:
- 九种PFAS与功能障碍标志物显著相关.
- perfluorooctanesulfonic 酸 (PFOS) 显示与多个脏标志物同时存在关联.
- PFAS混合物与不良的功能有关,炎症介导了这些影响.
- 生物信息学确定了脂质代谢和PPAR信号作为关键受影响的途径.
结论:
- 暴露于PFAS,特别是PFOS,与成人功能障碍有关.
- 炎症和脂质代谢失调是主要的介导机制.
- 这些发现为预防和管理与PFAS相关的脏疾病提供了机械洞察力.
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