在患有唐氏综合征的个体中,对下肢运动的高血压反应
Sara R Sherman1, Ronald E Jackson1, Brooks A Hibner1
1Integrative Physiology Laboratory, Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, Illinois, United States.
概括
患有唐氏综合征 (DS) 的人在运动期间显著减少了对活跃肌肉的血液流动,同时增加了对不活跃四肢的血液流动. 这表明自主功能障碍会影响DS患者的运动能力.
科学领域:
- 运动生理学 运动生理学
- 自主神经科学 自主神经科学
- 人体生理学 人体生理学
背景情况:
- 自主功能障碍在唐氏综合征 (DS) 中普遍存在.
- 有效的自主调节对于运动期间的血流和血压控制至关重要.
- 自主功能受损可能会影响DS患者的运动能力.
研究的目的:
- 为了研究下肢动力运动对股骨血流 (FaBF) 和血压 (BP) 在活跃和不活跃的四肢的影响.
- 为了在不同相对和绝对运动强度下,比较具有和没有DS的个体之间的这些反应.
- 了解自主调节在DS中运动反应中的作用.
主要方法:
- 24名DS患者和24名对照患者在最大动力功率的10%,20%和30% (相对强度) 和11Nm和16Nm (绝对强度) 进行了膝盖延伸.
- 用多普勒超声波测量两个四肢的骨血流 (FaBF).
- 评估了心跳对心跳平均动脉压 (MAP),并计算了大腿血管导电率 (FaVC).
主要成果:
- 患有DS的个体表现出显著减弱的FaBF (约. 55%较低) 和FaVC (大约55%较低) 的价格. 与对照组相比,在相对强度的运动中,活动四肢的体温下降了53%).
- 在FaBF中也有类似的减少 (约. 50%较低) 和FaVC (大约. 46%低) 在DS患者的绝对强度期间观察到.
- 患有DS的个体在较高相对强度的运动期间在非活动四肢中表现出更高的FaBF和FaVC,MAP没有显著的群体差异.
结论:
- 患有DS的个体在下肢动态炼期间表现出对将血液流向工作肌肉的能力受损.
- 在DS中观察到的非活动四肢血液流量的增加表明缺乏自主调节.
- 这些自主调节障碍可能会限制运动表现,并导致DS患者的工作能力下降.
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