孕产妇的产前胡卜素和儿童的肺功能:调整因素的探索
Xueying Zhang1,2, Terryl J Hartman3, Margaret Adgent4
1Department of Environment Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Thorax
|June 30, 2025
概括
产前胡卜素摄入可能会保护儿童的肺功能,特别是如果母亲在怀孕期间吸烟. 较高的胡卜素水平显示出与1秒内强制呼气体积 (FEV1) 的保护性关联.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 儿科肺病学 儿科肺病学
背景情况:
- 儿童呼吸道结果与产前营养有关.
- 胡卜素是强大的抗氧化剂,由于它们在修改这些结果中的作用而未得到充分研究.
- 了解营养对胎儿发育的影响对于长期健康至关重要.
研究的目的:
- 调查产前胡卜素水平与儿童 (8-9岁) 肺功能之间的关联.
- 评估母婴因素是否会改变这些关联.
- 为了探索特定的胡卜素 (α-胡卜素,β-胡卜素,β-加密素,柳科,泽亚素) 的作用.
主要方法:
- 在677个母婴二中测试的第二个三个月的血类胡卜素度.
- 测量儿童肺功能使用强制呼吸量在一秒内 (FEV1) 和强制生命能力 (FVC) z-score.
- 采用多变量线性回归,并通过母亲的吸烟,BMI,喘和孩子的性别来检查效果的改变.
主要成果:
- 在单个胡卜素和肺功能之间没有发现显著的主效应关联.
- 在所有五种胡卜素和FEV1之间观察到与母亲产前吸烟有关的显著相互作用 (p-相互作用<0.05).
- 更高的α-胡卜素与怀孕期间吸烟母亲的孩子的FEV1z分数增加有关.
结论:
- 产前胡卜素暴露在中儿童期与FEV1具有保护性关联,特别是在母亲在怀孕期间吸烟的儿童中.
- 怀孕期间母亲吸烟是产前胡卜素和儿童肺功能之间的关系的关键改变者.
- 对营养素-基因-环境相互作用的进一步研究对于儿童呼吸系统健康是有必要的.
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